Brahmi (Bacopa monnieri) has been in use since ancient times as a potent nerve tonic for rejuvenating mental health and promoting intellect and memory. Preclinical Neuropharmacological studies demonstrate that both the standardized extract and bacosides improve short-term and intermediate memories thus improving the long-term memory. The bacosides also significantly enhance protein synthesis in those regions of the brain, which are implicated in the memory formation, a possible explanation for its memory improving effect. Double blind cross over clinical studies have been carried out in children, elderly persons and normal healthy volunteers. Studies carried out in normal healthy volunteers, elderly subjects with age associated memory impairment and children with Attention Deficit Hyperactivity Disorder (ADHD) have shown that the drug was safe, well tolerated and efficacious. Study on children with ADHD has shown that the preparation significantly improves sentence repetition, logical memory and paired associate learning.
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