An in vivo study was conducted to evaluate the hepatoprotective activity of ethanolic extracts of Piper betel leaves. Liver damage was induced in male Wister rats weighed 150-200 gm by administering CCl4 (2ml/kg i.p) regularly for 10days and tissue damage was noted by various biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate Pyruvate transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Lipidperoxidation, Level of antioxidant enzy -me like catalase (CAT), Superoxide dismutase (SOD), Glutathione (GSH) in liver. Ethanolic extract of piper betel 100 mg/kg and 200 mg/kg i.p administered regularly for 10 days and compared with acontrol group silymarin (25 mg/kg i.p.).
A significant reduction in serum SGOT, SGPT, ALP, ACP, lipid peroxidation andimprovement in CAT, SOD, GSH, MDA level in the liver were observed when compared with CCl4 administered rats.Piper betel leaves extract (PBLE) was able to protect the liver against the oxidative damage produced by CCl4.
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